Process for manufacturing cis-isoambrettolide and use thereof

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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C07D31300

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active

061505382

ABSTRACT:
Manufacture of a molecule which is of important olfactory interest for perfumers. This molecule belongs to the group of macrocyclic lactones with a musk odor. The manufacturing process consists in preparing cis-16-hydroxy-9-hexadecenoic acid or an ester of this acid, which is a precursor of cis-isoambrettolide, the latter being obtained by macrolactonization in a very high degree of purity. Use as a fragrance material.

REFERENCES:
patent: 2417151 (1947-03-01), Collaud et al.
patent: 4014902 (1977-03-01), Tseng
Chemical Abstracts, vol. 98, No. 13, 1983 "Synthesis of Trans Delta9-Isoambrettolide" Majee et al., pp. 578.

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