Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1996-06-28
1997-09-30
Ford, John M.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
540222, C07D27756, C07D50136, C07D277593
Patent
active
056727119
ABSTRACT:
The objective of this invention is to provide a process of manufacturing cephem derivatives expressed by the following formula (1), wherein the compound (2) is reacted with an condensing agent of the compound (4) and 1-hydroxy-6-trifluoromethyl benzotriazole(5) and the mixture is acylated with 7-aminocephosporanic acid (3) or its derivatives. ##STR1## According to this invention, a desirous product with high purity may be obtained, which is more cost-saving and industrially feasible than the conventional methods, under the following process steps: Without protecting amino group of organic acid (2), conversion of the reactive derivatives under mild temperature is made and the acylation is directly carried out to obtain the final product.
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Jin Byung-Woo
Kim Jung-Woo
Lee Chong-Ryul
Park Ki-Seok
Qh Moo-Il
Chong Suet M.
Chong Kun Dang Corporation
Ford John M.
Nath Gary M.
Sripada Pavanaram K.
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