Process for manufacturing .alpha.-chloroarylacetic acids

Details Process for manufacturing .alpha.-chloroarylacetic acids Process for manufacturing .alpha.-chloroarylacetic acids

1977-12-28

1980-10-07

Myers, Jane S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

562492, 562488, 562478, 562496, C07C 5758

Patent

active

042270162

ABSTRACT:
Glyoxylic acid and hydrochloric acid are reacted with an aromatic compound having at least one substituent group selected from among the alkyl, aryl, hydroxy, alkoxy and aryloxy groups. The glyoxylic acid is used in a concentration comprised between 60 and 100% and the hydrochloric acid is used in as concentrated an aqueous solution as possible, e.g. in an organic solvent medium such as acetic acid. An acid catalyst such as zinc chloride may be used. The reaction may be carried out under pressure. The products are useful in various syntheses e.g. to produce amino acids or arylacetic acids with medicinal uses.

REFERENCES:
patent: 2876255 (1959-03-01), Johnston
patent: 3634504 (1972-01-01), Young
patent: 3637828 (1972-01-01), Holtschmidt et al.
patent: 4008269 (1977-02-01), Diamond et al.
Quelet, Bull. Soc. Chim. 1, 196-205 (1940). (CA, 1940, 5425).
Mar., Advanced Organic Chemistry: Reactions Mechanisms and Structure, pp. 424 and 421, (1968).

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