Process for manufacturing a flavone derivative

Details Process for manufacturing a flavone derivative Process for manufacturing a flavone derivative

1976-05-06

1978-03-07

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C07H 1500

Patent

active

040781372

ABSTRACT:
A process for manufacturing pure diosmin suitable as a therapeutic agent comprising acetylating hesperidin, observing by means of ultraviolet absorption the progress of the acetylation reaction and continuing such reaction until there disappears the band initially occurring at a wave length in the range of 264 to 280 nm and there appears in place thereof a new maximum at a wave length of about 330 nm. Thereafter the acetylation product is brominated, the obtained bromination product hydrolyzed and the obtained product after precipitation isolated, in order to obtain diosmin having a bromine content less than 0.1%.

REFERENCES:
patent: 3661890 (1972-05-01), Jurd
patent: 3751570 (1973-08-01), Leroi
"Chem. Ber." vol. 33, pp. 326-327, 1900.
Mitchell, "Chem. Abst." vol. 74, 1971, pp. 130, 372.

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