Process for manufacturing 1-(3-trifluoromethyl)-phenyl-propan-2-

Details Process for manufacturing 1-(3-trifluoromethyl)-phenyl-propan-2- Process for manufacturing 1-(3-trifluoromethyl)-phenyl-propan-2-

1997-04-17

1998-09-22

Geist, Gary

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

568309, 568323, C07C 4545

Patent

active

058115862

ABSTRACT:
A process for manufacturing 1-(3-trifluoromethyl)phenyl-propan-2-one intermediate in the synthesis of the anorexic drug fenfluramine consists of reacting the diazonium salt of 3-trifluoromethylaniline with isopropenyl acetate in a polar solvent in the presence of a catalytic amount of a cuprous salt and, optionally, of a base and purifying the crude product through the bisulfite complex or distillation under vacuum.

REFERENCES:
patent: 3198833 (1965-08-01), Beregi et al.
C.S. Rondestvedt, Jr., in Organic Reactions, Wiley, New York, vol. 24, Chapter 3, 1976.
Rondestvedt, Jr., Arylation of Unsaturated Systems by Free Radicals, Journal of American Chemical Society, &&, pp. 3401-3402, 1955.
Rondestvedt, Arylation of Unsaturated Compounds by Daizonium Salts, 1960.
Allard and Levisalles, Bulletin De La Societe Chimique De France, #5, pp. 1926-1931, 1972.
Raucher et al; Journal of Organic Chemistry; vol. 48, pp. 2066-2069, 1983.

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