Process for manufacture of telmisartan

Details Process for manufacture of telmisartan Process for manufacture of telmisartan

2007-03-20

2007-03-20

Shameem, Golam M. M. (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C548S300100, C548S301700, C548S302700

Reexamination Certificate

active

10802142

ABSTRACT:
A process for preparing telmisartan by reacting 2-n-propyl-4-methyl-6-(1′-methylbenzimidazol-2′-yl)benzimidazole with a compound of formula (IV)wherein Z is a leaving group, to obtain the compound 2-cyano-4′-[2″-n-propyl-4″-methyl-6″-(1′″-methylbenzimidazol-2′″-yl)benzimidazol-1″-ylmethyl]biphenyl, and subsequently hydrolyzing the nitrile function to obtain the acid function.

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patent: WO 00/43370 (2000-07-01), None
Cottineau, Bertrand, et al; Synthesis and Hypoglycemic Evaluation of Substituted Pyrazole-4-carboxylic Acids; Bioorganic and Medicinal Chemistry Letters, XP-002280950.
Mederski, Werner, W.K.R. et al; Non-Peptide Angiotensis II Receptor Antagonists: Synthesis and Biologicial Activity of a Series of Novel 4,5-Dihydro-4-oxo-3H imidazo[4,5-c]pyridine Derivatives. J. Med. Chem. 1994,037,01632-1645 XP 002129108.

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