Process for manufacture of racemic Carvedilol

Details Process for manufacture of racemic Carvedilol Process for manufacture of racemic Carvedilol

2011-01-25

2011-01-25

Saeed, Kamal A (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

07875730

ABSTRACT:
The invention relates to a novel process for the manufacture of Carvedilol of high HPLC purity (>99.5%) having individual impurity less than 0.1%. The product is isolated from reaction mass as a salt with suitable organic acids which on further purification is converted into the free base i.e., Carvedilol.

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Wei-Min, et al., “Synthesis and Crystal Structure of Carvedilol”, Chinese J. Struct. Chem., Sep. 1998, vol. 17, No. 5, pp. 325-328.
Chen, W.-M., et al., “Synthesis and Crystal Structure of Carvedilol”Chinese Journal of Structural Chemistry, vol. 17, No. 5 Sep. 1998, pp. 325-328.

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