Process for manufacture of fosinopril sodium

Details Process for manufacture of fosinopril sodium Process for manufacture of fosinopril sodium

2006-07-18

2006-07-18

Shameem, Golam M. M. (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

07078532

ABSTRACT:
The present invention discloses a process for the synthesis of fosinopril as a single desired isomer of high purity in two steps comprising of (a) preparation of fosinopril as a mixture of four diastereomers and (b) separation of the desired isomer from the mixture through formation of alkali metal salts followed by crystallisation.

REFERENCES:
patent: 4337201 (1982-06-01), Petrillo, Jr.
patent: 4873356 (1989-10-01), Petrillo et al.
patent: 5008399 (1991-04-01), Sedergran

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