Process for manufacture of 4-amino-hydroxybutylidene-1,...

Details Process for manufacture of 4-amino-hydroxybutylidene-1,... Process for manufacture of 4-amino-hydroxybutylidene-1,...

2006-12-27

2008-08-19

Saeed, Kamal (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

Reexamination Certificate

active

07414151

ABSTRACT:
The preset invention relates to a cost effective, high yielding, reproducible method for the manufacture of alendronic acid or its salt, such as sodium alendronate, from inexpensive and readily available pyrrolidone using phosphonating agents such as PCl3in the presence of acids such as sulphonic acids, sulphuric acid or phosphoric acid, and pharmaceutical dosage forms of alendronic acid or pharmaceutically acceptable salts thereof.

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Xu, et al, A Facile and Direct Synthesis of Alendronate From Pyrrolidone. OPPI Briefs. 2004, 36, 185-187.

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