Process for making vancomycin HC1

Details Process for making vancomycin HC1 Process for making vancomycin HC1

1992-04-27

1993-11-02

Chan, Y. Christina

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Separation or purification

530317, 530322, C07K 114, C07K 900

Patent

active

052584950

ABSTRACT:
A process for the manufacture of vancomycin.HCl which does not require preparation of a phosphate intermediate. The process consists of loading a vancomycin onto a suitable adsorbent and eluting the vancomycin solution therefrom with an ammonium solvent followed by loading the vancomycin solution onto a suitable adsorbent and eluting the purified, vancomycin solution therefrom with a solvent of alcohol and acid. The purified vancomycin is then crystallized from the solution by combining the solution with a sufficient amount of NH.sub.4 Cl to provide a pH of about 2.0 to about 3.5. The crystals are then dissolved in solution. The dissolved solution is combined with acid and the vancomycin recrystallizes from the solution.

REFERENCES:
patent: 3067099 (1962-12-01), McCormick et al.
patent: 4440753 (1984-04-01), McCormick et al.
patent: 4667024 (1987-05-01), Sitrin et al.
patent: 4845194 (1989-07-01), Glass et al.

Affiliated with

Also associated with

Rating

Process for making vancomycin HC1 does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for making vancomycin HC1, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for making vancomycin HC1 will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1758697