Process for making vancomycin

Details Process for making vancomycin Process for making vancomycin

1990-07-10

1992-09-22

Chan, Y. Christina

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Separation or purification

530317, 530322, C07K 114, C07K 900

Patent

active

051497840

ABSTRACT:
A process for the manufacture of vancomycin which does not require preparation of a phosphate intermediate. The process consists of loading a vancomycin onto a suitable adsorbent and eluting the vancomycin solution therefrom with an ammonium solvent followed by loading the solution onto a second adsorbent and eluting the purified, vancomycin therefrom with a solvent of alcohol and acid. The purified vancomycin is then crystallized by adding a base solution in an amount sufficient to raise the pH of the vancomycin/base solution to a pH of about 9.5 to 10.5 followed by the addition of an organic solvent such as methanol. The crystallized vancomycin is then reslurried in an aqueous solution and then recrystallized by adding a base solution in an amount sufficient to raise the pH to about 9.5 to about 10.5, followed by the addition of an organic solvent such as methanol. The recrystallized vancomycin is dissolved and titrated with hydrochloric acid to a pH of about 3.0 to 3.5. Vancomycin HCl is precipitated from the solution using an organic solvent.

REFERENCES:
patent: 3067099 (1962-12-01), McCormick et al.
patent: 4440753 (1984-04-01), McCormick et al.
patent: 4667024 (1987-05-01), Sitrin et al.
patent: 4845194 (1989-07-01), Glass et al.

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