Process for making vancomycin

Details Process for making vancomycin Process for making vancomycin

1995-02-10

1996-11-12

Chan, Christina Y.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Separation or purification

530317, 530322, C07K 114, C07K 900

Patent

active

055741355

ABSTRACT:
A process for the manufacture of vancomycin which does not require preparation of a phosphate intermediate. The process consists of passing a vancomycin broth through a suitable adsorbent, followed by passing the vancomycin through a second adsorbent, producing a purified vancomycin. Purified vancomycin is then crystallized from the solution by adding a base solution that imparts a pH of above about 9.0 to about 9.5 to the purified vancomycin. The crystallized vancomycin is separated from the solution, dissolved in solution and recrystallized by adding a base solution which imparts a pH of above about 9.0 to about 9.5 to the dissolved solution. The recrystallized vancomycin is dissolved and titrated with hydrochloric acid. Vancomycin. HCl is then precipitated from the solution using an organic solvent.

REFERENCES:
patent: 3067099 (1962-12-01), McCormick et al.
patent: 4440753 (1984-04-01), McCormick et al.
patent: 4667024 (1987-05-01), Sitrin et al.
patent: 4845194 (1989-07-01), Glass et al.
patent: 5149784 (1992-09-01), Chu

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