Process for making taxol derivatives

Details Process for making taxol derivatives Process for making taxol derivatives

1995-04-06

1997-01-14

Richter, Johann

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549511, C07D30514

Patent

active

055941575

ABSTRACT:
Process of making the compounds having the formula ##STR1## wherein --OR.sup.1 comprises the C-13 side-chain of taxol and R.sup.3 comprises hydrogen.

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Mathew, et al., "Synthesis and Evaluation of Some Water-Soluble Prodrugs and Derivatives of Taxol with Antitumor Activity", J. Med. Chem. 35:145-151 (1992).
Voegelein, et al., "Relationships Between the Stcuture of Taxol Analogues and Their Antimitotic Activity", J. Med. Chem. 34:992-998 (1991).
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CA 117(5):44581d, Zhang, et al. (Apr. 1992).
Della Casa de Marcano, et al., J. Chem. Soc. Comm, pp. 365-366 (1975).

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