Drug – bio-affecting and body treating compositions – Identification or warning feature – Taste or smell or chemical irritation to the eye – nose – or...
Patent
1984-01-16
1986-05-27
Rose, Shep K.
Drug, bio-affecting and body treating compositions
Identification or warning feature
Taste or smell or chemical irritation to the eye, nose, or...
264109, 264123, 264125, 424 14, 424 16, 424 19, 424 22, 424 78, A61K 3174, A61K 928, A61K 922, A61K 926
Patent
active
045914966
ABSTRACT:
A new method for making polymeric systems for the sustained release of macromolecular drugs is described. The method consists of mixing drug and polymer, e.g. ethylene-vinyl acetate copolymer powders below the glass transition temperature of the polymer, and compressing the mixture at a temperature above the glass transition point. The macromolecule is not exposed to organic solvent during the fabrication process. The sustained release and bioactivity of macromolecules is unchanged throughout the pressure casting and release processes.
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Little et al., "Tablet Making," 2nd ed. (1963), Northern Pub. Co., Liverpool, England, pp. 11-23, 29-33.
Cohen Jonathan M.
Langer Robert
Siegel Ronald
Cook Paul J.
Massachusetts Institute of Technology
Rose Shep K.
Smith, Jr. Arthur A.
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