Process for making systems for the controlled release of macromo

Drug – bio-affecting and body treating compositions – Identification or warning feature – Taste or smell or chemical irritation to the eye – nose – or...

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264109, 264123, 264125, 424 14, 424 16, 424 19, 424 22, 424 78, A61K 3174, A61K 928, A61K 922, A61K 926

Patent

active

045914966

ABSTRACT:
A new method for making polymeric systems for the sustained release of macromolecular drugs is described. The method consists of mixing drug and polymer, e.g. ethylene-vinyl acetate copolymer powders below the glass transition temperature of the polymer, and compressing the mixture at a temperature above the glass transition point. The macromolecule is not exposed to organic solvent during the fabrication process. The sustained release and bioactivity of macromolecules is unchanged throughout the pressure casting and release processes.

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patent: 4357312 (1982-11-01), Hsieh et al.
Little et al., "Tablet Making," 2nd ed. (1963), Northern Pub. Co., Liverpool, England, pp. 11-23, 29-33.

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