Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing oxygen-containing organic compound
Patent
1998-06-23
1999-10-05
Lilling, Herbert J.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing oxygen-containing organic compound
435134, 435145, 4351721, 4351723, 43525222, 435924, C12P 744, C12P 746, C12P 764
Patent
active
059622857
ABSTRACT:
Aliphatic polycarboxylic acids are made by a process comprising the steps of: (1) fermenting a beta-oxidation blocked C. tropicalis cell wherein both copies of the chromosomal POX5 gene and the chromosomal POX4A and POX4B genes are disrupted in a culture medium comprised of a nitrogen source, an organic substrate and a cosubstrate wherein the substrate is an unsaturated aliphatic compound having at least one internal carbon--carbon double bond and at least one terminal methyl group, a terminal carboxyl group and/or a terminal functional group which is oxidizable to a carboxyl group by biooxidation; (2) reacting the product of step (1) with an oxidizing agent to produce one or more polycarboxylic acids.
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Anderson Kevin W.
Fayter Richard G.
McVay Kenneth R.
Wenzel J. Douglas
Drach John E.
Henkel Corporation
Jaeschke Wayne C.
Lilling Herbert J.
Szoke Ernest G.
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