Process for making phenylthiopyrimidines

Details Process for making phenylthiopyrimidines Process for making phenylthiopyrimidines

1986-03-20

1988-05-31

Schwartz, Richard A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544300, 544301, 544302, 544310, 544312, 544313, 544314, 544317, 544318, C07D23938, C07D23956, C07D40312

Patent

active

047482451

ABSTRACT:
A process for the preparation of phenylthiopyrimidines which comprises: (a) reacting a thiopyrimidine; with sulfuryl chloride in the presence of a suitable solvent to form the sulfenyl chloride of said thiopyrimidine; (b) reacting said sulfenyl chloride of said thiopyrimidine with a phenol or substituted phenol, optionally in the presence of a Friedal-Crafts catalyst, to form a thiopyrimidinyl phenol; and (c) reacting said thiopyrimidinylphenol formed in step (b) with a base and an alkylating agent to form the end product.

REFERENCES:
patent: 4248618 (1981-02-01), Serban et al.
patent: 4427437 (1984-01-01), Serban et al.

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