Process for making perhydroindole-2-carbonxylic acid

Details Process for making perhydroindole-2-carbonxylic acid Process for making perhydroindole-2-carbonxylic acid

1987-10-21

1989-11-07

Springer, David B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548505, C07D20918

Patent

active

048793922

ABSTRACT:
A process for the asymmetric preparation of a compound of the formula ##STR1## wherein the hydrogen at 3a and 7a are of cis or trans configuration and their non-toxic, pharmaceutically acceptable acid addition salts comprising submitting a compound of the formula ##STR2## to a Hoffman reaction and reacting the resulting product with formaldehyde in the presence of cyanide ions and acid halide of benzoic acid or an aliphatic carboxylic acid of 1 to 5 carbon atoms to obtain a compound of the formula ##STR3## wherein R is acyl of benzoic acid or aliphatic carboxylic acid of 1 to 5 carbon atoms, cyclizing the latter to form a compound of the formula ##STR4## selectively hydrolyzing the latter with a dilute aqueous mineral acid to obtain a compound of the formula ##STR5## subjecting the latter to hydrolysis with a concentrated aqueous mineral acid to form the acid addition salt of a compound of claim 1 and optionally forming the free base.

REFERENCES:
patent: 2315661 (1943-04-01), Salzev et al.
patent: 4156016 (1979-05-01), Dalton et al.

Affiliated with

Also associated with

Rating

Process for making perhydroindole-2-carbonxylic acid does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for making perhydroindole-2-carbonxylic acid, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for making perhydroindole-2-carbonxylic acid will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-84855