Process for making peptides

Details Process for making peptides Process for making peptides

1995-05-26

1997-02-11

Schain, Howard E.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Synthesis of peptides

530328, 530333, C07K 104, C07K 106

Patent

active

056022310

ABSTRACT:
A process for the solid phase synthesis of peptides containing a C-terminal aza-amino acid, for example the decapeptide goserelin, which comprises:

REFERENCES:
patent: 4018754 (1977-04-01), Inouye et al.
patent: 4600705 (1986-07-01), Seprodi et al.
J-Chem. Soc. PTI, (1975), 1712-1720, Dutta et al.
Jones, "The Chemical Synthesis of Peptides", Activation and Coupling of Amino Acid Derivatives, 1991, pp. 55-58.
Gray et al, "Preparation and Properties of Some .alpha.-Aza-Amino-Acid Derivatives, Their Possible Use in Peptide Synthesis", Tetrahdron, vol. 33, 1977, pp. 739-743.
Niedrich et al, "Syhthese von Eledoisin-Octapeptiden mit den Carbazylresten Azaglycin und .alpha.-Azaasparagin statt Glycin und Asparagin", Journal f. prakt. Chemi. Band 314, Heft 5-6, 1972, S. 759-768.
Dutta et al, "Polypeptides. Part XIII..sup.1 Preparation of .alpha.-Aza-amino-acid (Carbazic Acid) Derivatives and Intermediates for the Preparation of .alpha.-Aza-peptides", Journal of the Chemical Society--Perkin I, 1975, pp. 1712-1720.
Gante, "Azapeptides", Synthesis, Jun. 1989, pp. 407-409.
Knolle et al., Solid Phase Synthesis of Glycosylated LHRH Antagonists with C-terminal Azaglycine-amide Peptides 1990, p. 414.
Knolle et al. Peptides (1990) 414.
Spatola, Chemistry and Biochemistry of Amino Acids, Peptides, and Proteins, (Weinstein, Ed.) (Marcel Dekker, Inc. 1983) 267-269:286-295.

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