Chemistry: molecular biology and microbiology – Carrier-bound or immobilized enzyme or microbial cell;...
Reexamination Certificate
2006-05-12
2009-06-09
Naff, David M (Department: 1657)
Chemistry: molecular biology and microbiology
Carrier-bound or immobilized enzyme or microbial cell;...
C435S176000, C435S177000, C435S178000, C435S179000, C435S180000, C435S182000, C530S811000, C530S812000, C530S813000, C530S814000, C530S815000, C530S817000, C424S400000, C424S423000, C424S484000
Reexamination Certificate
active
07544496
ABSTRACT:
The subject invention concerns a composite comprising an organic fluid-swellable, fibrous matrix, such as collagen, and a mineral phase, such as calcium carbonate or phosphate mineral phase, for use as a biomimetic of bone. In another aspect, the subject invention concerns a process for making a composite involving the inclusion of acidic polymers to a supersaturated mineralizing solution, in order to induce an amorphous liquid-phase precursor to the inorganic mineral, which is then absorbed (pulled by capillary action) into the organic matrix. Advantageously, once solidified, a high mineral content can be achieved, with the inorganic mineral crystals embedded within the collagen fibers (intrafibrillarly) and oriented such that they are aligned along the long axes of the fibers of the organic matrix, thereby closely mimicking the natural structure of bone. The present invention further concerns a method of treating a patient suffering from a bone defect by applying a biomimetic composite to the bone defect site.
REFERENCES:
patent: 4774227 (1988-09-01), Piez et al.
patent: 4795467 (1989-01-01), Piez et al.
patent: 4865602 (1989-09-01), Smestad et al.
patent: 4880610 (1989-11-01), Constantz
patent: 5147507 (1992-09-01), Gill
patent: 5178845 (1993-01-01), Constantz et al.
patent: 5273964 (1993-12-01), Lemons
patent: 5418222 (1995-05-01), Song et al.
patent: 5455231 (1995-10-01), Constantz et al.
patent: 5532217 (1996-07-01), Silver et al.
patent: 5593488 (1997-01-01), Wu
patent: 5800541 (1998-09-01), Rhee et al.
patent: 6071336 (2000-06-01), Fairchild et al.
patent: 6190633 (2001-02-01), Takahashi et al.
patent: 6201039 (2001-03-01), Brown et al.
patent: 6300315 (2001-10-01), Liu
patent: 6592712 (2003-07-01), Koukoulas et al.
patent: 6627170 (2003-09-01), Takahashi et al.
patent: 6995013 (2006-02-01), Connelly et al.
patent: 2003/0059362 (2003-03-01), Takahashi et al.
patent: 2003/0094252 (2003-05-01), Sundar et al.
patent: 2004/0020410 (2004-02-01), Gane et al.
patent: 2004/0052865 (2004-03-01), Gower et al.
patent: 2005/0152990 (2005-07-01), Gower et al.
patent: 0 143 363 (1985-06-01), None
patent: 0 233 770 (1990-05-01), None
patent: 0 197 693 (1991-10-01), None
patent: 0 270 254 (1993-03-01), None
patent: 03/035127 (2003-05-01), None
patent: WO 03/089022 (2003-10-01), None
Addadi, L. and S. Weiner “Control and Design Principles in Biological Mineralization”Agnew. Chem. Int. Ed. Engl. 1992, 31:153-169.
Addadi, L. et al. “A Chemical Model for the Cooperation of Sulfates and Carboxylates in Calcite Crystal Nucleation: Relevance to Biomineralization”PNAS USA, May 1, 1987, 84(9):2732-2736.
Addadi, L. et al. “Growth and Dissolution of Organic Crystals with ‘Tailor-Made’ Inhibitors—Implications in Stereochemistry and Materials Science”Angew. Chem. Int. Ed. Engl., 1985, 24:466-485.
Addadi, S. and S. Weiner “Interactions between Acidic Proteins and Crystals: Stereochemical Requirements in Biomineralization”PNAS USA, Jun. 15, 1985, 82(12):4110-4114.
Aizenberg, J. “Patterned crystallization of calcite in vivo and in vitro”J. Crystal Growth, 2000, 211:143-148.
Bianco, P. “Structure and Mineralization of Bone” in Calcification in Biological Systems, Bonnuci, E., Ed., Chapter 11, pp. 243-268, 1992, CRC Press, Inc., Boca Raton, FL.
Bradt, J-H. et al. “Biomimetic Mineralization of Collagen by Combined Fibril Assembly and Calcium Phosphate Formation”Chem. Mater., 1999, 11:2694-2701.
Carlson, S.J. “Vertebrate Dental Structures” in Skeletal Biomineralization: Patterns, Processes and Evolutionary Trends Carter, J.G., Ed., Chapter 21, pp. 531-556, 1990, Van Nostrand Reinhold, New York, NY.
Deng, Y. et al. “Study on the three-dimensional proliferation of rabbit articular cartilage-derived chondrocytes on polyhydroxyalkanoate scaffolds”Biomaterials, 2002, 23:4049-4056.
Dickinson, R.B. et al. “Biased Cell Migration of Fibroblasts Exhibiting Contact Guidance in Oriented Collagen Gels”Annals. Biomed. Engin., 1994, 22:342-356.
Francillon-Vieillot, H. et al. “Microstructure and Mineralization of Vertebrate Skeletal Tissues” in Skeletal Biomineralization: Patterns, Processes and Evolutionary Trends Carter, J.G., Ed., Chapter 20, pp. 471-530, 1990, Van Nostrand Reinhold, New York, NY.
Gower, L. and D. Odom “Deposition of calcium carbonate films by a polymer-induced liquid-precursor (PILP) process”J. Crystal Growth, 2000, 210:719-734.
Gower, L. and D. Tirrell “Calcium carbonate films and helices grown in solutions of poly(aspartate)”J. Crystal. Growth, 1998, 191:153-160.
Gower, L. “The Influence of Polyaspartate Additive on the Growth and morphology of Calcium Carbonate Crystals” Doctoral Dissertation, 1997, University of Massachusetts at Amherst.
Greenfield, E.M. et al. “Ionotropic Nucleation of Calcium Carbonate by Molluscan Matrix”Amer. Zool., 1984, 24:925-932.
Guido, S. and R. Tranquillo “A methodology for the systematic and quantitative study of cell contact guidance in oriented collagen gels”J. Cell Sci., 1993, 105:317-331.
Jones, D. and U. Walter “The Silicate Garden Reaction in Microgravity: A Fluid Interfacial Instability”J. Colloid and Interface Sci., 1998, 203:286-293.
Katz, E.P. et al. “The Structure of Mineralized Collagen Fibrils”Connective Tissue Res., 1989, 21:149-158.
Landis, W.J. et al. “Mineral and Organic Matrix Interaction in Normally Calcifying Tendon Visualized in Three Dimensions by High-Voltage Electron Microscopic Tomography and Graphic Image Reconstruction”J. Struct. Biol., 1993, 110:39-54.
Landis, W.J. et al. “Topographic Imaging of Mineral and Collagen in the Calcifying Turkey Tendon”Connective Tissue Res., 1991, 25:181-196.
Mann, S. “Mineralization in Biological Systems”Structure and Bonding, 1983, 54:125-174.
Mann, S. “Crystallochemical Strategies in Biomineralization” in Biomineralization: Chemical and Biochemical Perspectives, Mann, S et al., Eds., Chapter 2, pp. 35-62, 1989, VCH Publishers, New York, N.Y.
Murthy, N.S. “Liquid Crystallinity in Collagen Solutions and Magnetic Orientation of Collagen Fibrils”Biopolymers, 1984, 23:1261-1267.
Nehrer, S. et al. “Chondrocyte-seeded collagen matrices implanted in a chondral defect in a canine model”Biomaterials, 1998, 19:2313-2328.
Oh, Y.R. and O.O. Park “Transient Flow Birefringence of Calf Skin Collagen Solutions”J. Chem. Eng. Jpn., 1992, 25(3):243-250.
Olszta, M.J. et al. “A New Paradigm for Biomineral Formation: Mineralization via an Amorphous Liquid-Phase Precursor”Connective Tissue Res., 2003, 44(Suppl. 1):326-334.
Olszta, M. “Biomimetic Mineralization of Collagen for Nanostructured Composites” poster materials, Jun. 2001, Department of Materials Science and Engineering, University of Florida, Gordon Research Conference.
Sciadini, M.F. et al. “Evaluation of Bovine-Derived Bone Protein with a Natural Coral Carrier as a Bone-Graft Substitute in a Canine Segmental Defect Model”J. Orthopaedic Res., 1997, 15:844-857.
Sivakumar, M. and K Panduranga Rao “Preparation, characterization and in vitro release of gentamicin from coralline hydroxyapatite-gelatin composite microspheres”Biomaterials, 2002, 23:3175-3181.
Tranquillo, R.T. et al. “Magnetically orientated tissue-equivalent tubes: application to a circumferentially orientated media-equivalent”Biomaterials, 1996, 17:349-357.
Traub, W. et al. “Origin of Mineral Crystal Growth in Collagen Fibrils”Matrix, 1992, 12:251-255.
Traub, W. et al. “Three-Dimensional Ordered Distribution of Crystals in Turkey Tendon Collagen Fibers”PNAS USA, Dec. 15, 1989, 86(24):9822-9826.
Weiner, S. et al. “Lamellar Bone: Structure-Function Relations”J. Struc. Biol., 1999, 126:241-255.
Weiner, S. and W. Traub “Bone structur
Douglas Elliot P.
Gower Laurie B.
Munisamy Sivakumar
Olszta Matthew J.
Wheeler Donna L.
Naff David M
Saliwanchik Lloyd & Saliwanchik
University of Florida Research Foundation Inc.
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