Process for making optically active naphtho[1,2-b][1,4]thiazepin

Details Process for making optically active naphtho[1,2-b][1,4]thiazepin Process for making optically active naphtho[1,2-b][1,4]thiazepin

1988-05-10

1989-09-05

Bond, Robert T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

540491, 546150, C07D149273

Patent

active

048640581

ABSTRACT:
A process for preparing optically active naphtho[1,2-b][1,4]thiazepin-4(5H)-ones comprising resolution of rac-.beta.-[(2-amino-1-naphthalenyl)thio]-.alpha.-hydroxy-4-methoxybenzene propanoic acid and converting the optically active acids so obtained into final products is described. The end product naphtho[1,2-b][1,4]thiazepin-4(5H)-ones have activity as calcium channel blockers and accordingly are useful as agents for lowering blood pressure, and as agents for treating ischemia.

REFERENCES:
patent: 4652561 (1987-03-01), Mohacsi et al.
Helvetica Chimica Acta, Colume 39, Fasciculus II (1956) No. 49, pp. 429-440.
DE 3337-176A (Abstract).
J61069756A (Abstract).
ES8500250A (Abstract).

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