Process for making optically active .alpha.-amino ketones

Details Process for making optically active .alpha.-amino ketones Process for making optically active .alpha.-amino ketones

1992-06-15

1994-11-15

Cintins, Marianne M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

560 39, 560 24, 560 32, 560 81, 560115, 560127, 560190, 560193, 562401, 562442, 562451, C07C23311, C07D29518, B01J 3124

Patent

active

053649613

ABSTRACT:
The invention includes selected novel optically active .alpha.-amino ketones which either are themselves useful or are intermediates for the preparation of known ketomethylene pseudopeptides useful as antibiotics, antibiotic enhancers, or enzyme inhibitors. Further, the present invention provides a method for dehydrogenation/asymmetrical hydrogenation to obtain essentially pure antipodes of ketomethylene pseudopeptides having two chiral centers.

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