Process for making .omega.-chloro-2,3,4-trihydroxyacetophenone

Details Process for making .omega.-chloro-2,3,4-trihydroxyacetophenone Process for making .omega.-chloro-2,3,4-trihydroxyacetophenone

1976-06-24

1978-12-12

Trousof, Natalie

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

26034622, 260592, C07D31178, C07C 4978

Patent

active

041295765

ABSTRACT:
8-Methoxypsoralen is prepared in six steps from pyrogallol including condensation of pyrogallol with a two-fold excess of chloroacetic acid with boron trifluoride hydrogenation of 6,7-dihydroxy-2,3-dihydrobenzofuran and dehydrogenation of 2,3-dihydroxanthotoxin. Improvements in these three steps lead to a marked overall increase in yield.

REFERENCES:
lagercrantz, Acta Chemica Scandinavica 10, 1956, pp. 647-654.
House, Modern Synthetic Reactions, 2nd Edition, 1972, p. 3 and pp. 37-40.
Buu-Hoi et al, J. Org. Chem. 20, (1955), pp. 606-609.
Davies et al, J. Chem. Soc., 1950, pp. 3202-3206.

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