Process for making o-arylbenzonitriles

Details Process for making o-arylbenzonitriles Process for making o-arylbenzonitriles

1998-03-31

1999-02-23

Richter, Johann

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitriles

C07C25500

Patent

active

058746064

ABSTRACT:
Disclosed is a method of making an o-arylbenzonitrile. A mixture is prepared of o-chlorobenzonitrile and about 1.0 to about 2.0 equivalents per equivalent of o-chlorobenzonitrile of a substituted phenylmagnesium halide in about 5 to about 30 mL per gram of o-chlorobenzonitrile of a solvent system of an ethereal solvent and N-methyl pyrrolidinone. The o-chlorobenzonitrile is reacted with the substituted phenylmagnesium halide at a temperature of about 10-.degree. to about 25.degree. C.

REFERENCES:
patent: 5288895 (1994-02-01), Bousset et al.
patent: 5380910 (1995-01-01), Kageyama
Cram, D.J., et al, "Host-Guest Complexation: 29 Expanded Hemispherands", JACS, 106(11), 3287-3292, 1984.
Katz, H.E., "Chelate and Macrocycle Effects in the 2,2'-Bipyridine N,N'-Dioxide complexation of Alkyltin Trichlorides", JOC, 50, 2086-2091, 1985.

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