Process for making mycophenolate mofetil by transesterification

Details Process for making mycophenolate mofetil by transesterification Process for making mycophenolate mofetil by transesterification

2006-03-28

2006-03-28

McKane, Joseph K. (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

Reexamination Certificate

active

07019133

ABSTRACT:
A process for making mycophenolate mofetil comprising: conducting a catalytic transesterification by reacting a low-carbon alkyl ester of mycophenolic acid with 2-morpholinoethanol [also named as 4-(2-hydroxyethyl) morpholine] to obtain a crude product of mycophenolate mofetil, which is then isolated and purified.

REFERENCES:
patent: 4753935 (1988-06-01), Nelson et al.
patent: 5247083 (1993-09-01), Knox et al.
patent: 5380879 (1995-01-01), Sjogren
patent: WO 00/34503 (2000-06-01), None
patent: WO03042393 (2003-05-01), None
Jerry March, Advanced Organic Chemistry, 1985, 3rdEd., pp. 348-353.

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