Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1996-07-31
2000-04-04
Kunz, Gary L.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536119, 536124, 546 44, C07D48900, C07H 1302, C07H 100, C07G 300
Patent
active
060463139
ABSTRACT:
##STR1## Morphine-6-glucuronide or substituted morphine-6-glucuronide of formulae (I) is made by conjugation of a glucuronate ester and/or substituted glucuronate ester with morphine or substituted morphine in the presence of a Lewis acid catalyst and in the absence of silver catalysts and barium hydroxide and other heavy metal derivatives.
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Vlahov, J., and Snatzke, G., "Uber eine verbesserte Synthese von .beta.-Glucosiduronsaure-Derivaten", Liebigs Ann. Chem., 1983, 570-574.
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Osborne, R., et al., "Analgesic Activity of Morphine-6-Glucuronide", The Lancet, 1988, 828.
Carrupt, P-A., et al, "Morphine-6-Glucuronide and Morphine 3-Glucuronide as Molecular Chameleons with Unexpected Lipophilicity", J. Med. Chem., 1991, 34, 1272-1275.
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Brown Richard Talbot
Carter Neil Edward
Lumbard Keith William
Mayalarp Stephen Patrick
Scheinmann Feodor
Kunz Gary L.
Salford Ultrafine Chemicals and Research Limited
White Everett
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