Process for making montelukast and intermediates therefor

Details Process for making montelukast and intermediates therefor Process for making montelukast and intermediates therefor

2006-11-20

2009-10-13

Desai, Rita J (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C546S180000

Reexamination Certificate

active

07601741

ABSTRACT:
The reaction of methylmagnesium halide is improved by the presence of a cerium (III) salt such as cerium trichloride. The reactions are typically associated with the production of montelukast, a pharmaceutically useful compound of the following formulaand salts thereof. Further enhancements can be derived from certain intermediates, salts thereof and/or purification thereof before and/or after the reaction involving methylmagnesium halide.

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