Process for making mesna, dimesna and derivatives thereof

Details Process for making mesna, dimesna and derivatives thereof Process for making mesna, dimesna and derivatives thereof

1998-06-30

1999-07-13

Geist, Gary

Organic compounds -- part of the class 532-570 series

Organic compounds

Phosphorus acids or salts thereof

562 30, 562 8, 562101, 562103, 568 26, C07F 938

Patent

active

059229020

ABSTRACT:
A process for synthesizing disulfides and sulfhydryl compounds which are useful pharmaceuticals. The process includes a two step, single pot process for preparing disulfides from an alkenyl sulfonate salt. The disulfides are useful as toxicity mitigating agents of chemotherapeutic drugs, such as certain platinum complexes, and as use therapeutic drugs for a variety of conditions in mammals.
The two step process involves first the conversion of the starting reagent to a mercaptane sulfonate, then an oxidation to the desired disulfide.

REFERENCES:
patent: 2517934 (1950-08-01), Schulze
patent: 3978137 (1976-08-01), Frame
patent: 4670602 (1987-06-01), Louthan
CA:90:86742, abs of PL94610, Dec. 1977.

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