Process for making mesna, dimesna and derivatives thereof

Details Process for making mesna, dimesna and derivatives thereof Process for making mesna, dimesna and derivatives thereof

1997-09-24

1998-09-15

Geist, Gary

Organic compounds -- part of the class 532-570 series

Organic compounds

Phosphorus acids or salts thereof

562 20, 562 30, 562101, 562103, 562108, 568 26, 568 18, C07F 938

Patent

active

058081402

ABSTRACT:
A process for synthesizing disulfides and sulfhydryl compounds which are useful pharmaceuticals. The process includes a two step, single pot process for preparing disulfides from an alkenyl sulfonate salt. The disulfides are useful as toxicity mitigating agents of chemotherapeutic drugs, such as certain platinum complexes, and as use therapeutic drugs for a variety of conditions in mammals.
The two step process involves first the conversion of the starting reagent to a mercaptane sulfonate, then an oxidation to the desired disulfide.

REFERENCES:
patent: 3994979 (1976-11-01), Warner
CA:122:264627, abs of "The synthesis of unsymmetric and symmetric disulfides", Ternay, Phosphorus ,Sulfur Silicon Rel Elem, 95&96 (1-4), pp. 1042-6507, 1994.
CA:67:90729, abs of "Synthesis of water-soluble trisulfides", Fedoseeva, Ukr. Khim. Zh., 33(6), pp. 596-597, 1967.
CA:103:37096, abs of SU1130561 Dec. 1984.

Affiliated with

Also associated with

Rating

Process for making mesna, dimesna and derivatives thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for making mesna, dimesna and derivatives thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for making mesna, dimesna and derivatives thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-89909