Process for making lyophilized radiographic imaging kit

Details Process for making lyophilized radiographic imaging kit Process for making lyophilized radiographic imaging kit

1982-12-08

1985-04-09

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

424 9, 424131, A61K 4900, A61K 4902, A61K 4300

Patent

active

045101256

ABSTRACT:
A process for making a lyophilized composition useful for skeletal imaging whereby an aqueous solution containing an ascorbate, gentisate, or reductate stabilizer is contacted with tin metal or an alloy containing tin and, thereafter, lyophilized. Preferably, such compositions also comprise a tissue-specific carrier and a stannous compound. It is particularly preferred to incorporate stannous oxide as a coating on the tin metal.

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patent: 4314986 (1982-02-01), Ruddock
Kempi, et al., "99mTc-DTPA(Sn) Dry Kit Preparation" Nuclear Medizin, 13, 389-399 (1975).
Tomita, et al., "The Preparation of 99mTc-Sulfur-Colloid by Reduction with Metallic Tin", Radioisotopes, 25, 49-50 (1975).
Persson, et al., "Labelling Plasmin with Technetium-99m for Scintigraphic Localization of Thrombi", Intl. J. of Applied Radiation & Isotopes, 28, 97-104 (1977).
Ikeda, et al., "A New Preparation Method for .sup.99m Tc-Phytate", J. of Nuclear Medicine, 17, 389-393 (1976).
van den Brand, et al., "The Influence of Experimental Conditions on the Formation of Various 99mTc(Sn)EHDP Complexes", Intl. J. of Applied Radiation & Isotopes, 33, 39-45 (1982).

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