Process for making L-phenyl acetyl carbinol (PAC), microorganism

Details Process for making L-phenyl acetyl carbinol (PAC), microorganism Process for making L-phenyl acetyl carbinol (PAC), microorganism

1991-06-12

1994-05-17

Lilling, Herbert J.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing oxygen-containing organic compound

435156, 435921, 435942, C12P 726, C12P 722

Patent

active

053127420

ABSTRACT:
Mutations are induced in a microorganism selected from the species Saccharomyces cerevisiae or from the species Candida flareri. The resulting mutants are cultured in the presence of a fermentation inhibitor, such as acetaldehyde, ephedrine or PAC-dione, to form colonies having resistance to the inhibitor. Cells from the colonies are isolated and tested for yield of phenyl acetyl carbinol (PAC) in a fermentation with benzaldehyde and pyruvate. Yeast cells from the colonies that produce elevated levels of PAC are selected for use in subsequent fermentations. PAC is useful as an intermediate in the preparation of l-ephedrine and d-pseudoephedrine, two well-known medicinal chemicals.

REFERENCES:
patent: 5079145 (1992-01-01), Seely et al.
Chem Abs. 97: 161037k (1982) Netrval et al.
Chem Abs 106: 192466h (1989) Ellaiah et al.
Chem Abs 110: 113139k (1989) Long et al.

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