Process for making insoluble gas-filled microspheres containing

Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Ultrasound contrast agent

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424 951, 424489, 424491, 424499, 264 4, 264 41, 264 43, 264 432, 264 433, 264 44, 264 46, 264 47, 428402, 4284022, 42840221, 4272133, 42721331, 42721333, A61K 4904, B01J 1302, B32B 516

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active

059651091

ABSTRACT:
The present invention relates to a process for making insoluble gas-filled, pressure-resistant microspheres containing a liquid or solid hydrophobic barrier within the microsphere shell, and products of this process. This barrier serves to decrease the rate of gas exchange between the microsphere and the aqueous environment surrounding the microsphere and thus enhances resistance to pressure due to gas exchange.

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