Process for making human antibody producing B-lymphocytes

Details Process for making human antibody producing B-lymphocytes Process for making human antibody producing B-lymphocytes

1981-03-12

1984-04-24

Naff, David M.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

435 68, 435241, C12N 500, C12N 502, C12P 2100

Patent

active

044448872

ABSTRACT:
Antibody producing human B-lymphocytes are produced by a process which comprises culturing human B-lymphocytes in a tissue culture medium in the presence of an antigen; helper signal producing agents comprising monocytes or monocyte conditioned medium containing Interleukin 1 (I1-1), and helper T-lymphocytes or helper T-lymphocyte replacing factor; and human serum; and thereafter recovering the antibody producing cells from the medium.

REFERENCES:
Hoffman et al., Production of Antibody to Sheep Red Blood Cells by Human Tonsil Cells in Vitro-Nature, vol. 243, 1973 (pp. 408-409).
Luzzati et al., Indication of Plaque-Forming Cells in Cultured Human Lymphocytes by Combined Action of Antigen and EB Virus, Nature, vol. 269, 1977 (pp. 419-420).
Heinitz et al., EB Virus-Induced B Lymphocyte Cell Lines Producing Specific Antibody, Nature, vol. 269, 1977 (pp. 420-422).

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