Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...
Patent
1995-05-18
1997-03-18
McKane, Joseph
Organic compounds -- part of the class 532-570 series
Organic compounds
Nitrogen attached directly or indirectly to the purine ring...
544388, 544390, C07D40106
Patent
active
056124848
ABSTRACT:
A process for making a clinically efficacious HIV protease inhibitor Compound J eliminates one step in its synthesis, by an improved, alternative synthesis of the 2(S)-4-picolyl-2-piperazine-t-butyl-carboxamide intermediate.
REFERENCES:
Giraud-Clenet, et al., Compt. Rend., t. 262, pp. 224-227, 1966.
Krimen, et al., "The Ritter Reaction", Organic Reactions, vol. 17, pp. 213-325, 1969.
Mowry, et al., "The Preparation of Nitriles", Chem. Rev., 42, pp. 189-283, 1947.
Ugi, et al., "The Passerini and Ugi Reactions", Comprehensive Organic Synthesis, vol. 4, pp. 1083-1109, 1991.
Askin David
Reider Paul J.
Rossen Kai
Sager Jess
Volante Ralph P.
Appollina Mary A.
McKane Joseph
Merck & Co. , Inc.
Myers, Jr. Richard S.
Winokur Melvin
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