Process for making HIV protease inhibitors

Details Process for making HIV protease inhibitors Process for making HIV protease inhibitors

1995-06-21

1996-03-05

McKane, Joseph K.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544349, 544360, 544365, 544117, 544119, 544120, 544121, 544124, 544128, 544131, 544137, 546146, 546270, 548217, C07D24102

Patent

active

054969484

ABSTRACT:
Intermediates of structural formula ##STR1## can be made by reacting glycidol or an activated derivative thereof with an amide. The process and intermediates are useful for synthesizing HIV protease inhibitor compounds.

REFERENCES:
CA 116:256007a Highly . . . HIV-1 protease, Askin et al., pp. 835-836, 1992.
CA 119:9166s Stereo selective . . . epoxides. Askin et al., p. 947, 1993.

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