Process for making fluorinated 4-azasteroid derivatives

Details Process for making fluorinated 4-azasteroid derivatives Process for making fluorinated 4-azasteroid derivatives

2007-11-27

2007-11-27

Seaman, D. Margaret (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

11410179

ABSTRACT:
The present invention relates to synthetic processes useful in the preparation of fluorinated 4-azasteroid derivatives that modulate androgen receptors and have application in the treatment of conditions caused by androgen deficiency or androgen receptor hyperactivity, such as osteoporosis, periodontal disease, bone fracture, frailty, erectile dysfunction, loss of libido, androgen-dependent cancers and sarcopenia. The present invention also encompasses intermediates useful in the disclosed synthetic processes and the methods of their preparation.

REFERENCES:
patent: 7186838 (2007-03-01), Meissner et al.
King, A.O. et al., J. Org. Chem. 1993, vol. 58, pp. 3384-3386.
Lal, G.S. et al., J. Org. Chem. 1999, vol. 64, pp. 7048-7054.
Pogany, S.A. et al., Synthesis, 1987, vol. 8, pp. 718-719.
Wilkinson, J.A., Chem. Rev., 1992, vol. 92, pp. 505-519.

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