Process for making dihydropyrimidinones

Details Process for making dihydropyrimidinones Process for making dihydropyrimidinones

1996-12-12

1998-07-28

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C07D23936

Patent

active

057864721

ABSTRACT:
The present invention provides a process for forming 5-(alkyl or alkoxy)carbonyl-6-alkyl-4-(aryl or alkyl)-3,4-2(1H)-dihydropyrimidinones by combining a .beta.-keto ester or diketone, an aldehyde and urea in the presence of a boron reagent, a metal salt (e.g., Cu.sub.2 O) and a catalyst (e.g., acid). The reaction is typically run in one pot in a solvent to afford dihydropyrimidinones in higher yields and with easier work up than previously known methods.

REFERENCES:
patent: 4675321 (1987-06-01), Baldwin et al.

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