Process for making chiral alpha-amino phosphonates selected nove

Details Process for making chiral alpha-amino phosphonates selected nove Process for making chiral alpha-amino phosphonates selected nove

1992-06-15

1994-06-14

Dees, Jose G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Phosphorus acids or salts thereof

556 18, 558131, 558145, 558170, 558172, 562 15, C07F 938, C07F 940

Patent

active

053211537

ABSTRACT:
This invention is selected novel chiral (essentially pure) alpha-amino phosphonates, process for the preparation which is a catalytic asymmetric hydrogenation of olefins and novel intermediates therefor. The alpha-amino phosphonates are useful as antibiotics and/or as intermediates in the preparation of phosphorus-containing analogs of peptides, i.e., phosphonopeptides or pseudopeptides having known uses, such as in antibiotics, antibiotic enhancers, or enzyme inhibitors.

REFERENCES:
patent: 4142992 (1979-03-01), Knowles et al.
patent: 4397787 (1983-08-01), Riley
Dhawan et al., Phosphorus and Sulfur, 32, pp. 119-144 (1987).
Yamamoto, Organotransition Metal Chemistry, John Wiley & Sons (1986), p. 365.

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