Process for making chiral alpha-amino phosphonates and selected

Details Process for making chiral alpha-amino phosphonates and selected Process for making chiral alpha-amino phosphonates and selected

1995-03-22

1997-12-30

Geist, Gary

Organic compounds -- part of the class 532-570 series

Organic compounds

Phosphorus esters

558172, 560 24, 560 29, 560 32, 562 75, C07F 940, C07F 938

Patent

active

057032637

ABSTRACT:
This invention is selected novel chiral (essentially pure) alpha-amino phosphonates, process for the preparation which is a catalytic asymmetric hydrogenation of olefins and novel intermediates therefor. The alpha-amino phosphonates are useful as antibiotics and/or as intermediates in the preparation of phosphorus-containing analogs of peptides, i.e., phosphonopeptides or pseudopeptides having known uses, such as in antibiotics, antibiotic enhancers, or enzyme inhibitors.

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