Process for making chiral 1,4-disubstituted piperazines

Details Process for making chiral 1,4-disubstituted piperazines Process for making chiral 1,4-disubstituted piperazines

2007-08-14

2007-08-14

Bernhardt, Emily (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C544S377000, C544S394000, C560S172000

Reexamination Certificate

active

11147055

ABSTRACT:
A process for a stereoselective preparation of novel chiral nitrogen mustard derivatives useful in synthesizing optically active 1,4-disubstituted piperazines of formula:wherein R, Ar, and Q are defined as set forth herein, and intermediate compounds therefor. The 1,4-disubstituted piperazines act as 5HT1A receptor binding agents useful in the treatment of Central Nervous System (CNS) disorders. The intermediate compounds of Formula II and IV as set forth herein are also included.

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