Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1997-11-14
1998-12-08
Prats, Francisco C.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536123, 536124, 536126, 5361231, 514 54, 435101, 4242441, C07H 108, C08B 3700, C12P 1904, A61K 3909
Patent
active
058471120
ABSTRACT:
Type-specific capsular polysaccharide preparations from Streptococcus pneumoniae, having on average less than about 1000 oligosaccharide repeat units per molecule, polydispersities between 1.0 and 1.4, intrinsic viscosities between 0.6 and 3.0 dL/g, and less than 3% contamination of type-specific polysaccharide by group-specific C-polysaccharide, are produced by a novel process. The novel type specific polysaccharide products are useful in the preparation of vaccines, especially covalent conjugates comprising the novel polysaccharide linked to a T-cell stimulatory carrier protein. Vaccines comprising the novel polysaccharides are useful in the prevention of infection and of diseases associated with infection by Streptococcus pneumoniae.
REFERENCES:
patent: 4221906 (1980-09-01), Querry et al.
patent: 4242501 (1980-12-01), Cano et al.
patent: 4271147 (1981-06-01), Helting et al.
patent: 4459286 (1984-07-01), Hilleman et al.
patent: 4496538 (1985-01-01), Gordon
patent: 4619828 (1986-10-01), Gordon
patent: 4644059 (1987-02-01), Gordon
patent: 4686102 (1987-08-01), Ritchey et al.
patent: 4695624 (1987-09-01), Marburg et al.
patent: 4707543 (1987-11-01), Zollinger et al.
patent: 4711779 (1987-12-01), Porro et al.
patent: 4727136 (1988-02-01), Jennings et al.
patent: 4755381 (1988-07-01), Cryz
patent: 4830852 (1989-05-01), Marburg et al.
patent: 4882317 (1989-11-01), Marburg et al.
patent: 5034519 (1991-07-01), Beuvery et al.
Szu et al, "Ultrasonic Irradiation . . . ", Carbohydr. Res. vol. 152, pp. 7-20 (1986).
Pediatric Research, 29:179A (1991).
Lifely, M. R. et al. Vaccine, 9: 60-66 (1991).
Frasch, C. E. et al. The Journal of Infectious Diseases, 158: 710-718 (1988).
The Journal of Infectious Diseases, 165: 152-155 (1992).
Porro, et al., Jour Biol. Standardization, 11: pp. 65-74 (1983).
Fattom, et al. Infection & Immunity, 58: No. 7 pp. 2309-2312 (1990).
Snippe, et al Infection & Immunity, 42 No. 2 pp. 842-844, (1983).
J. G. Howard et al., Immunology, 1971, 21, pp. 535-546.
P. Chabrecek et al., Chromatographia, Aug. 1990, 30, pp. 201-204.
E. A. Kabat and A. E. Bezer, Archives of Biochemistry and Biophysics, 78, pp. 306-318, 1958.
O. Makela et al., Scand. J. Immunol., 19, 541-550, 1984.
Gerald Zon et al., Infect. Immun., 37, pp. 89-103, Jul. 1982.
Manssur Yalpani, Studies in Org.Chem., 36, pp. 368-405, 1988.
S. Marburg et al., Am.Chem.Soc., 108, pp. 5282-5287, 1986.
Burke Pamela D.
Hagopian Arpi
Hennessey, Jr. John P.
Ip Charlotte C.
Kniskern Peter J.
Coppola Joseph A.
Merck & Co. , Inc.
Prats Francisco C.
Tribble Jack L.
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