Process for making camptothecin derivatives

Details Process for making camptothecin derivatives Process for making camptothecin derivatives

2006-04-18

2006-04-18

Kifle, Bruck (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

07030243

ABSTRACT:
A process for synthesizing highly lipophilic derivatives of camptothecin. The process includes reacting dissolved, underivatized camptothecin with a silylated heterocyclic compound in a modified Minisci-type alkylation reaction to produce 7-substituted derivatives of camptothecin.

REFERENCES:
patent: 6194579 (2001-02-01), Hausheer
patent: 6723849 (2004-04-01), Narkunan et al.

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