Process for making bisphosphonic acids using diluents other...

Details Process for making bisphosphonic acids using diluents other... Process for making bisphosphonic acids using diluents other...

2006-05-02

2006-05-02

Barts, Samuel (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C546S022000

Reexamination Certificate

active

07038083

ABSTRACT:
Provided is a novel method of making bisphosphonic acids, e.g. risedronic acid, including the step of combining a carboxylic acid, phoshorous acid, and a halophosphorous compound in the presence of a diluent that is an aromatic hydrocarbon or a silicone fluid. When the diluent is an aromatic hydrocarbon, a inert support or ortho-phosphoric acid codiluent is advantageously included.

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