Process for making Biolimus A9

Details Process for making Biolimus A9 Process for making Biolimus A9

2011-01-18

2011-01-18

Kifle, Bruck (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

Reexamination Certificate

active

07872122

ABSTRACT:
A process for making Biolimus A9 comprises reacting sirolimus (or rapamycin) with alkyl benzene sulfonate under the catalyzing of organic base and in the presence of organic solvent to undergo a nucleophilic substitution reaction to obtain the Biolimus A9 with high yield, not only for small-scale laboratory experiment, but also for rendering reproducibility of high yield even after process amplification.

REFERENCES:
patent: 7193078 (2007-03-01), Isozaki et al.

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