Process for making asenapine

Details Process for making asenapine Process for making asenapine

2011-01-25

2011-01-25

Kosack, Joseph R (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C549S354000

Reexamination Certificate

active

07875729

ABSTRACT:
Asenapine and related trans-isomer bicyclic compounds can be obtained by reducing a compound of formula (C) to preferentially form a trans-isomer compound of formula (D), followed by subsequent ring closure to form a compound of formula (B) such as asenapine.

REFERENCES:
patent: 4145434 (1979-03-01), van der Burg
patent: 1 710 241 (2006-10-01), None
patent: WO 95/23600 (1995-09-01), None
patent: WO 99/32108 (1999-07-01), None
Th. de Boer et al., “Antipsychotic Dopamine D2 Receptor Antagonist 5-HT2 Receptor Antagonist” Drugs of the Future 1993, 18(12): 1117-1123.
C. W. Funke et al., “Physico-chemical Properties and Stability of trans-5-Chloro-2-methyl-2,3,3a,12b-tetra . . . ” Arzneim-Forsch/Drug Res., 40(1) Nr. 5 (1990) pp. 536-539.

Affiliated with

Also associated with

Rating

Process for making asenapine does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for making asenapine, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for making asenapine will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2644603