Process for making antimicrobial quinolonyl lactams

Details Process for making antimicrobial quinolonyl lactams Process for making antimicrobial quinolonyl lactams

1993-05-07

1994-01-25

Richter, Johann

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540201, 540215, 540217, 540219, 540222, 540223, 540224, 540225, 540316, 540304, 540310, 540312, 540313, 540314, 540315, 540317, 540346, C07D49904, C07D49908, C07D49912, C07D20512

Patent

active

052817032

ABSTRACT:
The present invention provides methods of making compounds of the structure

REFERENCES:
Sandler & Kairo, "O-Carbamates", Organic Functional Group Preparations, vol. II, Chap. 11, pp. 235-242, 1971.
S. Kukolja et al., "Oral Absorption of Cephalosporin Antibiotics, 1. Synthesis, Biological Properties, and Oral Bioavailability of 7-(Arylacetamido)-3-chloro Cephalosporins in Animals", J. Med. Chem. vol. 31, pp. 1987-1993, 1988.
S. Schmitt et al., "The Synthesis of 2-(Functionalized Methyl)-1.beta.-Methyl-Carbapenems", J. Antibiotics, vol. 41, p. 780, 1988.
D. G. Walker et al., "Use of Bistrimethylsilylated Intermediates in the Preparation of Semisynthetic 7-Amino-3-substituted-cephems. Expedient Syntheses of a new 3-[1-Methyl-1-pyrrolidinio)methyl]cephalosporin", J. Org. Chem., vol. 53, pp. 983-991, 1988.
M. Alpegiani et al., "2-(Heteroatom-substituted)Methyl Penems. IV. Oxygen Derivatives", Heterocycles, vol. 30, No. 2, pp. 799-812, 1990.
A. J. Corraz et al., "Dual-Action' Penems", Abstract-825, 31st Interscience Conference on Antibacterial Agents and Chemotherapy, Oct. 1, 1991.
A. J. Corraz et al., "Dual-Action' Penems and Carbapenems", Abstract-826, 31st Interscience Confernce on Antibacterial Agents and Chemotherapy, Oct. 1, 1991.
A. J. Corraz et al., Handout distributed at poster presentation, 31st Interscience Conference on Antibacterial Agents and Chemotherapy, Oct. 1, 1991.
A. J. Corraz et al., "Dual-Action Penems and Carbapenems", J. Med. Chem., vol. 35, pp. 1828-1839, 1992.

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