Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1995-08-08
1998-03-17
Daus, Donald G.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C07D26352
Patent
active
057288402
ABSTRACT:
A process for synthesizing the epoxide of the formula ##STR1## consists of, at a minimum, formation of a halohydrin from the allyl acetonide reactat, followed by base-induced cyclization, the epoxide product I being useful as an intermediate for the synthesis of inhibitors of renin or HIV protease or other proteases.
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Masuda, et al., J. Org. Chem. 1994, 59(19), 5550-5555.
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Askin et al Tetrah. Lett. vol. 35 pp. 673-676 (Feb. 1994).
Askin David
Eng Kan K.
Maligres Peter E.
Reider Paul J.
Rossen Kai
Appollina Mary A.
Daus Donald G.
Merck & Co. , Inc.
Tribble Jack L.
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