Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-02-22
2005-02-22
Morris, Patricia L. (Department: 1625)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
active
06858738
ABSTRACT:
Amlodipine and related analogues thereof are prepared by the following general reaction scheme:R1and R2each independently represent a C1-C4alkyl group. The process provides for the formation of compounds of formula (1) in good yield and purity. Further, the compounds of formula (1) can be used as calcium channel blockers or as reference standards or reference markers for checking the purity of amlodipine.
REFERENCES:
patent: 4572909 (1986-02-01), Campbell et al.
patent: 4818766 (1989-04-01), Ostermayer et al.
patent: 4879303 (1989-11-01), Davison et al.
patent: 4983740 (1991-01-01), Peglion et al.
patent: 5155120 (1992-10-01), Lazar et al.
patent: 5389654 (1995-02-01), Furlan et al.
patent: 5424321 (1995-06-01), Hellberg et al.
patent: 5438145 (1995-08-01), Furlan et al.
patent: 6046337 (2000-04-01), Bozsing et al.
patent: 6479525 (2002-11-01), Lemmens et al.
patent: 6518288 (2003-02-01), Lemmens et al.
patent: 6538012 (2003-03-01), Ettema
patent: 6600047 (2003-07-01), Benneker et al.
patent: 6602893 (2003-08-01), Lemmens et al.
patent: 0 089 167 (1986-10-01), None
patent: 0 244 944 (1990-01-01), None
patent: 0 290 211 (1991-09-01), None
patent: 0 534 520 (1997-03-01), None
patent: 0 902 016 (1999-03-01), None
patent: 0 963 980 (1999-12-01), None
patent: 1266654 (2002-12-01), None
patent: 1287826 (2003-03-01), None
patent: 002677 (2001-01-01), None
patent: 2161156 (2000-12-01), None
patent: 9925688 (1999-05-01), None
patent: 9952873 (1999-10-01), None
patent: 0024714 (2000-05-01), None
patent: 0035873 (2000-06-01), None
patent: 0035910 (2000-06-01), None
Alker et al., “Long-acting dihydropyridine calcium antagonists. 9. Structure activity relationships around amlodipine,” Eur J Med Chem (1991) 26, 907-913.
Amlodipine Besylate Monograph, PHARMEUROPA vol. 10, No. 2, 197-198, Jun. 1998.
Faulkner et al., “Absorption of Amlodipine Unaffected by Food,” Arzneim Forsch/Drug Res. 39 (11), No. 7, (1989).
McDaid and Deasy, “Formulation development of transdermal drug delivery system for amlodipine base,” International Journal of Pharmaceutics 133 (1996) 71-83.
Arrowsmith et al., “Long-Acting Dihydropyridine Calcium Antagonists. 1.2-Alkoxymethyl Derivatives Incorporating Basic Substitutents,” J. Med. Chem. American Chemical Society, 1986, 29, 1696-1702.
FDA FOIA Material on Amlodipine Besylate, NDA No. 19-787, “Review of an Original NDA,” Oct. 10, 1990.
Bartl Jiri
Benneker Franciscus B. G.
Peters Theodorus H. A.
Slanina Pavel
Buscher Mark R.
Synthon BV
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