Process for making a stable pharmaceutical preparation of prosta

Details Process for making a stable pharmaceutical preparation of prosta Process for making a stable pharmaceutical preparation of prosta

1988-10-06

1989-10-03

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

514785, 514786, 514970, A61K 3119, A61K 31557, A61K 4700

Patent

active

048717720

ABSTRACT:
A process for making a stable pharmaceutical preparation of prostaglandin E compounds and/or 15R forms thereof is diclosed.
Prostagladin E compounds and 15R forms thereof are know to have useful pharmacological actions even if they are used in a vary small amounts. However, they are extremely unstable and, therefore, considerably difficult in application for routine clinical purposes.
In order to remove this difficulty, prostagladin E compounds and 15R forms thereof are formulated into a stable preparation by filling a hard capsule with a solution or a suspension thereof.

REFERENCES:
patent: 3450821 (1969-06-01), Carslensen et al.
patent: 3815052 (1974-11-01), Monkhouse
patent: 3880906 (1975-04-01), Spraggins
patent: 3903297 (1975-09-01), Robert
patent: 4045577 (1977-08-01), Spraggins
patent: 4092425 (1978-05-01), Stringfellow
patent: 4335097 (1982-06-01), David et al.
Encyclopedia of Chemical Technology, 3rd edition (1984), pp. 712-714, 738-743.

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