Process for making a lyophilized product for use in skeletal ima

Details Process for making a lyophilized product for use in skeletal ima Process for making a lyophilized product for use in skeletal ima

1982-06-10

1985-03-12

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

424 9, 422 61, A61K 4300, A61K 4900

Patent

active

045044627

ABSTRACT:
A process for making a lyophilized composition, useful for skeletal imaging containing diphosphonates, stannous reductant, and an ascorbate or reductate stabilizer. The process comprises (1) preparing an aqueous solution of diphosphonate, reductant, and stabilizer, (2) adjusting the pH of the solution formed in step one to a pH in the range from about 5.5 to about 6.5, and (3) lyophilizing the pH adjusted solution.

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