Process for making a cyclodextrin

Details Process for making a cyclodextrin Process for making a cyclodextrin

1998-06-29

2000-11-28

Lee, Howard C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

514 58, C07H 100

Patent

active

061537462

ABSTRACT:
Sulfoalkyl ether cyclodextrins are produced by a process of treating an unsubstituted cyclodextrin starting material with an alkyl sultone in the presence of a base. The base is added in a stepwise, pH controlled manner so that substantially the entire initial charge of cyclodextrin starting material is at least partially reacted. Additional base is then added to complete the reaction, and residual alkyl suftone is destroyed. The product advantageously contains low levels of both residual cyclodextrin and residual alkyl sultone.

REFERENCES:
patent: 3426011 (1969-02-01), Parmerter et al.
patent: 5134127 (1992-07-01), Stella et al.
patent: 5376645 (1994-12-01), Stella et al.
Rajewski et al. "Preliminary Safety Evaluation of Parenterally Administered Sulfoalkyl Ether .beta.-Cyclodextrins Derivatives", J. Pharm. Sci, vol. 84(8):927-932.

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